DotNet Core + Angular 2 (final release) for frontend, Express and MongoDB for Rest Api (backend), ready for debugging (client side & server side) in Visual Studio 2015 Update 3
npm install generator-dotnetcore-angular2-express-mongodb* Frontend: Asp.Net Core + Angular 2 (final release) + TypeScript
* Backend: NodeJs/Express Rest API + MongoDB + TypeScript
> If you want to have Visual Studio 2015 full end-to-end debuggability but also NodeJS Express for you backend REST Api (instead of Asp.Net MVC)
$ npm install -g generator-dotnetcore-angular2-express-mongodb
$ mkdir your-project-name
$ cd your-project-name
$ yo dotnetcore-angular2-express-mongodb
This works great - if you also want to have your REST api in c# (probably going for Entity Framework for your data layer).
If you want to have a NodeJS/Express application as your backend (utilizing MongoDB as data store) it gets complicated. The easy way would be to just host your frontend (Angular 2 app) with NodeJS Express too. Unfortunately the end-to-end debugging experience is not yet there with NTVS (Node Tools for Visual studio).
Best way to achive my requirements was to create separate projects for the frontend (hosted by Asp.Net Core) and backend REST Api (hosted by NodeJs Express).
Additional benefit of this approach is the possibility to share code between frontend and backend. We can now share DTOs between Angular 2 code and backend persistence code :)