open-genes-mcp

MCP (Model Context Protocol) client for Open Genes AI — access 7,500+ aging and longevity genes directly from Claude Desktop, Cursor, or Claude Code.

No API keys required! All requests are proxied through the Open Genes API.

Installation

Add to your MCP configuration file:

$3

Edit ~/.claude/claude_desktop_config.json:

``json
{
"mcpServers": {
"open-genes": {
"command": "npx",
"args": ["open-genes-mcp"]
}
}
}
`

$3

Edit .cursor/mcp.json in your project or global config:

`json
{
"mcpServers": {
"open-genes": {
"command": "npx",
"args": ["open-genes-mcp"]
}
}
}
`

$3

Edit ~/.claude/claude_code_config.json:

`json
{
"mcpServers": {
"open-genes": {
"command": "npx",
"args": ["open-genes-mcp"]
}
}
}
`

Available Tools

Once configured, you'll have access to these tools:

| Tool | Description |
|------|-------------|
| search_genes | Search genes by name, symbol, or keyword |
| get_gene | Get detailed info about a specific gene |
| get_gene_researches | Get research data for a gene |
| search_lifespan_experiments | Search lifespan experiments |
| compare_genes | Compare 2-5 genes |
| get_database_stats | Database statistics |
| semantic_search_genes | AI-powered semantic search |
| find_similar_genes` | Find functionally similar genes |

Example Queries

After installation, you can ask Claude:

- "What genes are involved in DNA repair and affect lifespan?"
- "Tell me about SIRT1 and its role in aging"
- "Find genes similar to FOXO3"
- "Compare SIRT1, SIRT3, and SIRT6"
- "What are the best-studied longevity genes?"

Database

Open Genes contains:
- 7,500+ genes associated with aging and longevity
- 2,500+ lifespan experiments on model organisms
- 23 hallmarks of aging (aging mechanisms)
- 300+ diseases with gene associations
- 22,500+ semantic embeddings for AI search

Links

- Web App: https://open-genes-ai.onrender.com
- Open Genes Database: https://open-genes.com
- GitHub: https://github.com/DanilaImmortalist/open-genes-ai

License

MIT